Clinical platform trials for coronavirus (COVID-19) treatments
Past and current clinical trials into therapeutic and antiviral treatments for COVID-19, how to take part, and which treatments have proven to be effective.
Closure of the COVID-19 Antivirals and Therapeutics Taskforce on 31 March 2023
In line with the government바카라 사이트檚 strategy of living with COVID-19, the COVID-19 Antivirals and Therapeutics Taskforce closed on 31 March 2023.
Find out more about on the National Institute for Health and Care Research (NIHR) website.
Find out more about on the NHS website.
About clinical trials
Clinical trials are essential to finding new and improved methods of treating different diseases including coronavirus (COVID-19).
Clinical trials allow us to understand whether new treatments:
- genuinely improve recovery and survival for patients who contract COVID-19
- should be made available more widely in the NHS
Phase 1 and 2 trials
Phase 1 and 2 trials are early-stage trials involving small numbers of participants to ensure a treatment is safe to use and shows evidence of a benefit beyond the standard of care.
Treatments that are found to be safe at this stage may then proceed to be tested in a phase 3 clinical trial.
Phase 3 trials
Phase 3 trials involve large numbers of patients and assess whether a treatment is effective enough to be used more widely in the NHS.
Clinical platform trials for COVID-19 treatments in the UK
The National Institute for Health and Care Research (NIHR) established a single UK-wide process to prioritise COVID-19 research as Urgent Public Health research early in the COVID-19 pandemic. The purpose was to:
- prevent duplication of effort
- ensure the UK is running large enough trials to get definitive answers to key questions
The바카라 사이트疌OVID-19 Antivirals and Therapeutics Taskforce바카라 사이트痺orked with NIHR and other partners to horizon scan and monitor national and international developments in COVID-19 antivirals and therapeutics.
The Department of Health and Social Care (DHSC) is continuing to support a series of national clinical trial 바카라 사이트榩latforms바카라 사이트� across all phases of human trials and in a range of patient cohorts. These are assessing several therapeutic and prophylactic candidates, and are supported by the NIHR Clinical Research Network across the UK to identify and enrol patients.
The trial platforms are co-ordinated in a streamlined manner so that treatments can move through phase 1, 2 and 3 trials. This provides a clear route for treatments to progress rapidly from small to large-scale trials to prove safety and efficacy in treating COVID-19.
Individuals from research organisations can make proposals for promising COVID-19 treatments to be considered for addition to any of the바카라 사이트�UK바카라 사이트痗linical trial platforms.
See the Medicines and Healthcare products Regulatory Agency바카라 사이트檚 guidance on바카라 사이트痗linical trials applications for coronavirus (COVID-19).
Each of the clinical trial platforms is assessing a range of potential COVID-19 treatments. Further information can be found on the individual trial websites.
AGILE
is a phase 1 and 2 clinical trial that aims to identify the safe dosage for new COVID-19 treatments, and determine whether each treatment shows evidence of a benefit beyond the standard NHS care in small patient numbers.
RECOVERY
The trial is the world바카라 사이트檚 largest randomised controlled clinical trial for COVID-19 treatments, having recruited over 39,000 participants in its first year of running.
Participants in this trial are patients who have been admitted to hospital with moderate to severe COVID-19.
Treatments that are found to be effective in RECOVERY will be made available in the NHS to treat those with severe COVID-19 in hospital.
RECOVERY+
The RECOVERY+ trial is an extension of the larger phase 3 trial platform . RECOVERY+ is a phase 2 trial testing promising COVID-19 treatments for hospitalised patients.
Treatments that are successful in phase 2 trials as part of RECOVERY+ will be rapidly considered for addition to the phase 3 trials in RECOVERY to prove safety and efficacy in large patient numbers.
REMAP-CAP
is an international phase 3 trial testing treatments in patients with severe COVID-19 infection in intensive care units. Treatments that are found to be effective in REMAP-CAP will be made available in the NHS to reduce mortality and accelerate recovery in COVID-19 patients.
PRINCIPLE
is a phase 3 trial testing treatments in the community. The PRINCIPLE trial is investigating treatments that could prevent mild COVID-19 infection from becoming more serious, and participants in this trial are COVID-19 patients who have not been admitted to hospital.
If a treatment is found to be effective in PRINCIPLE, it will be made available in NHS primary care to improve health outcomes and reduce the number of patients who need to be admitted to hospital.
PROTECT-V
is a phase 3 trial testing prophylactic interventions for COVID-19 in vulnerable renal and immunocompromised patients. It aims to test their effectiveness at reducing infections at events such as regular hospital check-ups or dialysis appointments.
Any treatment found to be effective as part of this platform will improve COVID-19 treatment for this vulnerable cohort of the population.
HEAL-COVID
is a phase 3 trial testing potential treatments to determine whether they can improve the longer-term outcomes for patients who have been discharged from hospital after recovering from COVID-19.
This is part of the DHSC바카라 사이트檚 effort to not only ensure that patients survive but return to full health post-COVID.
STIMULATE-ICP
(symptoms, trajectory, inequalities and management: understanding long COVID to address and transform existing integrated care pathways) is a phase 3 trial that is currently being set up at University College London Hospitals NHS Trust.
It will be the largest long COVID trial to date, recruiting more than 4,500 people with the condition.
It will test the effectiveness of existing drugs to treat long COVID by measuring the effects of 3 months바카라 사이트� treatment, including on people바카라 사이트檚 symptoms, mental health and outcomes such as returning to work. It will also assess the use of MRI scans to help diagnose potential organ damage, as well as enhanced rehabilitation through an app to track their symptoms.
PANORAMIC
is a UK-wide study sponsored by the University of Oxford and funded by the NIHR to find out in which people new community-based antiviral treatments for COVID-19 reduce the need for hospital admission and improve outcomes.
How to take part in a clinical trial
Find out if you바카라 사이트檙e eligible to take part in a clinical trial on the NIHR바카라 사이트檚 .
There were a number of ground-breaking clinical trial results obtained through our national clinical trials infrastructure during the pandemic. These ensured that UK patients were able to access treatments as soon as they became available.
Results of trials to date: effective and ineffective treatments
In June 2020, the RECOVERY trial identified dexamethasone as the world바카라 사이트檚 first effective treatment for COVID-19.
Since then, there have been positive findings on tocilizumab from the REMAP-CAP and RECOVERY trials.
Effective treatments
Table 1: summary of treatments that have been found to be effective in treating COVID-19, as part of the UK clinical trial platforms
| Date | Treatment | Trial | Patient cohort | Further guidance |
|---|---|---|---|---|
| 6 October 2022 | Molnupiravir | PANORAMIC | Non-hospitalised patients | |
| 3 March 2022 | Baricitinib |
RECOVERY | Hospitalised patients | |
| 17 September 2021 | Ronapreve DHSC press release: Thousands of patients to benefit from life-saving COVID-19 treatment |
RECOVERY | 听 | Hospitalised patients who have not mounted an antibody response against COVID-19 |
| 16 June 2021 | REGEN-COV | RECOVERY | Hospitalised patients with severe COVID-19 who are seronegative (that is, have not mounted a natural antibody response) | |
| 12 April 2021 | Inhaled budesonide |
PRINCIPLE | COVID-19 patients in the community who are 65 and over or 50 and over with an underlying health condition | |
| 11 February 2021 | Tocilizumab |
RECOVERY |
Hospitalised patients who are receiving oxygen and are hypoxic | DHSC press release: Thousands more NHS patients to get life-saving COVID-19 treatment |
| 7 January 2021 | Tocilizumab and sarilumab |
REMAP-CAP |
Patients in intensive care |
DHSC press release: NHS patients to receive life-saving COVID-19 treatments that could cut hospital time by 10 days |
| 16 June 2020 | Dexamethasone |
RECOVERY |
Hospitalised patients requiring oxygen or ventilator support |
DHSC press release: world-first coronavirus treatment approved for NHS use by government |
Ineffective treatments
Robust clinical trials are critical to building an evidence base of what does and does not work. It is of equal importance to reach conclusions on the ineffectiveness of potential COVID-19 treatments in order to deliver the best possible care to patients.
Table 2: summary of treatments that have been found to be ineffective in treating COVID-19, as part of the UK clinical trial platforms
| Date | Treatment | Trial | Patient cohort |
|---|---|---|---|
| 22 November 2022 | Apixaban | HEAL-COVID |
Hospitalised patients |
| 8 June 2021 | Aspirin | RECOVERY |
Hospitalised patients |
| 5 March 2021 | Colchicine | RECOVERY |
Hospitalised patients |
| 25 January 2021 | Doxycycline |
PRINCIPLE |
Patients aged over 65 (or over 50 with an underlying health condition) in the community |
| 25 January 2021 | Azithromycin |
PRINCIPLE |
Patients aged over 65 (or over 50 with an underlying health condition) in the community |
| 15 January 2021 | Convalescent plasma | RECOVERY+ |
Hospitalised patients |
| 11 January 2021 | Convalescent plasma |
REMAP-CAP |
Patients in intensive care units |
| 22 December 2020 | Heparin | REMAP-CAP | Severely ill patients in intensive care units requiring oxygen support |
| 14 December 2020 | Azithromycin |
RECOVERY |
Hospitalised patients |
| 29 June 2020 | Lopinavir/ritonavir | RECOVERY |
Hospitalised patients |
| 5 June 2020 | Hydroxychloroquine | RECOVERY |
Hospitalised patients |
Further information
- (NIHR)
Updates to this page
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Updated to reflect that the Antivirals and Therapeutics Taskforce closed on 31 March 2023. Removed section on 'Identifying candidates for clinical trials'.
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Updated Table 1 to include interim results for molnupiravir from the PANORAMIC clinical trial.
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First published.