Research and analysis
NOIDs causative agents: week 12 (week ending 23 March 2025)
Updated 24 April 2025
© Crown copyright 2025
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This publication is available at /government/publications/notifiable-diseases-causative-agents-reports-for-2025/noids-causative-agents-week-12-week-ending-23-march-2025
The Week 12 causative agents report has been re-produced due to some data errors. As the report was created at a later date (27 March 2025) there may also be some changes into the data due to retrospective reporting of causative agents in Week 12.
Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:
- Bacillus anthracis
- Bacillus cereus
- Bordetella pertussis
- Borrelia spp
- Brucella spp
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter spp
- Carbapenemase-producing Gram-negative bacteria
- Chikungunya virus
- Chlamydophila psittaci
- Clostridium botulinum
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- Corynebacterium ulcerans
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Cryptosporidium spp
- Dengue virus
- Ebola virus
- Entamoeba histolytica
- Escherichia coli O 157
- Francisella tularensis
- Giardia spp
- Guanarito virus
- Haemophilus influenzae (invasive)
- Hanta virus
- hepatitis A
- hepatitis B
- hepatitis C
- hepatitis D
- hepatitis E
- influenza virus
- Junin virus
- Kyasanur Forest disease virus
- Lassa virus
- Legionella spp
- Leptospira interrogans
- Listeria monocytogenes
- Machupo virus
- Marburg virus
- measles virus
- mpox virus
- mumps virus
- Mycobacterium tuberculosis complex
- Neisseria meningitidis
- Omsk haemorrhagic fever virus
- Plasmodium falciparum
- Plasmodium Knowlesi
- Plasmodium Malariae
- Plasmodium Ovale
- Plasmodium Vivax
- polio virus
- Rabies virus
- Rickettsia spp
- Rift Valley fever virus
- Rubella virus
- Sabia virus
- Salmonella spp
- SARS coronavirus
- Shigella spp
- Streptococcus group A (invasive)
- Streptococcus pneumoniae (invasive)
- Varicella zoster virus
- Variola virus
- Vibrio cholerae
- West Nile virus
- Yellow fever virus
- Yersinia pestis
Statutory Notifications of causative agents, grouped by root organism
Totals for the current week compared to the previous 5.
| Week notification received | 2025/08 | 2025/09 | 2025/10 | 2025/11 | 2025/12 |
|---|---|---|---|---|---|
| Arboviruses | Ìý | Ìý | Ìý | Ìý | Ìý |
| West Nile Virus | 1 | 1 | - | - | - |
| Bacillus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Bacillus cereus | 18 | 14 | 16 | 15 | 19 |
| Bordetella | Ìý | Ìý | Ìý | Ìý | Ìý |
| Bordetella pertussis | 12 | 7 | 9 | 13 | 4 |
| Borrelia | Ìý | Ìý | Ìý | Ìý | Ìý |
| Borrelia burgdorferi | 28 | 19 | 11 | 18 | 19 |
| Borrelia sp | 3 | 7 | 3 | 3 | 2 |
| Brucella | Ìý | Ìý | Ìý | Ìý | Ìý |
| Brucella sp | - | 4 | - | 4 | 1 |
| Campylobacter | Ìý | Ìý | Ìý | Ìý | Ìý |
| Campylobacter coli | 32 | 23 | 29 | 33 | 32 |
| Campylobacter fetus | - | 1 | - | - | - |
| Campylobacter jejuni | 303 | 297 | 305 | 309 | 283 |
| Campylobacter other named | 2 | 3 | 2 | 2 | - |
| Campylobacter rectus | - | 1 | - | - | - |
| Campylobacter sp | 933 | 1,032 | 1,037 | 1,111 | 1,011 |
| Campylobacter upsaliensis | 1 | 4 | - | 3 | 1 |
| Campylobacter ureolyticus (bacteroides corrodens) | - | - | - | - | 1 |
| Chikungunya virus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Chikungunya virus | 1 | 2 | 1 | 1 | 1 |
| Clostridium | Ìý | Ìý | Ìý | Ìý | Ìý |
| Clostridium perfringens | 42 | 31 | 24 | 37 | 40 |
| Coronavirus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Coronavirus | 236 | 238 | 189 | 170 | 150 |
| Human coronavirus 229e | - | 1 | 1 | - | - |
| Human coronavirus hku1 | 2 | 1 | 5 | 1 | - |
| Human coronavirus oc43 | - | - | - | - | 1 |
| SARS-CoV-2 antibody indeterminate | 2 | - | 2 | 6 | - |
| SARS-CoV-2 antibody void | 12 | 14 | 26 | 34 | 34 |
| SARS-CoV-2 coronavirus (COVID-19) | 928 | 909 | 921 | 895 | 1,071 |
| SARS-CoV-2 coronavirus (COVID-19) indeterminate | 48 | 41 | 55 | 42 | 60 |
| SARS-CoV-2 IgG antibody negative | 27 | 7 | 11 | 9 | 2 |
| SARS-CoV-2 IgG antibody positive | 83 | 32 | 60 | 63 | 45 |
| SARS-CoV-2 total antibody negative | 12 | 8 | 4 | 12 | - |
| SARS-CoV-2 total antibody positive | 13 | 8 | 8 | 41 | 29 |
| Corynebacterium | Ìý | Ìý | Ìý | Ìý | Ìý |
| Corynebacterium diphtheriae | 3 | 3 | 1 | 4 | 5 |
| Corynebacterium ulcerans | - | 1 | - | - | - |
| Coxiella | Ìý | Ìý | Ìý | Ìý | Ìý |
| Coxiella burnetii | - | - | 1 | - | - |
| Cryptosporidium | Ìý | Ìý | Ìý | Ìý | Ìý |
| Cryptosporidium hominis | 4 | 4 | 2 | 2 | 4 |
| Cryptosporidium parvum | 17 | 17 | 11 | 12 | 18 |
| Cryptosporidium sp | 17 | 28 | 40 | 40 | 36 |
| Cryptosporidium ubiquitum | 1 | - | 2 | - | - |
| Entamoeba | Ìý | Ìý | Ìý | Ìý | Ìý |
| Entamoeba histolytica | 3 | 2 | 6 | 2 | 1 |
| Escherichia | Ìý | Ìý | Ìý | Ìý | Ìý |
| Escherichia coli O 157 | 6 | 7 | 10 | 10 | 10 |
| Flaviviruses | Ìý | Ìý | Ìý | Ìý | Ìý |
| Dengue virus | 5 | 5 | 1 | 2 | - |
| Giardia | Ìý | Ìý | Ìý | Ìý | Ìý |
| Giardia sp | 106 | 95 | 123 | 123 | 106 |
| Haemophilus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Haemophilus influenzae | 76 | 79 | 84 | 91 | 78 |
| Hepatitis viruses | Ìý | Ìý | Ìý | Ìý | Ìý |
| Hepatitis A | 18 | 18 | 18 | 13 | 13 |
| Hepatitis B | 298 | 278 | 289 | 302 | 306 |
| Hepatitis C | 287 | 214 | 278 | 291 | 281 |
| Hepatitis D | 9 | 3 | 9 | 8 | 6 |
| Hepatitis E | 34 | 45 | 39 | 59 | 27 |
| Influenza virus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Influenza A | 2,208 | 1,808 | 1,657 | 1,351 | 1,310 |
| Influenza B | 2,192 | 2,045 | 1,649 | 1,435 | 1,235 |
| Influenza indeterminate | 1 | - | 1 | - | - |
| Influenza ungrouped | 75 | 75 | 59 | 40 | 50 |
| Legionella | Ìý | Ìý | Ìý | Ìý | Ìý |
| Legionella pneumophila | 1 | 7 | 11 | 6 | 4 |
| Legionella sp | - | 1 | 7 | 2 | 5 |
| Leptospira | Ìý | Ìý | Ìý | Ìý | Ìý |
| Leptospira interrogans | - | - | - | 1 | - |
| Listeria | Ìý | Ìý | Ìý | Ìý | Ìý |
| Listeria monocytogenes | 5 | 2 | 8 | 3 | 5 |
| Mycobacterium | Ìý | Ìý | Ìý | Ìý | Ìý |
| Mycobacterium tuberculosis | 84 | 98 | 92 | 90 | 79 |
| Neisseria | Ìý | Ìý | Ìý | Ìý | Ìý |
| Neisseria meningitidis | 33 | 29 | 17 | 33 | 41 |
| Orthopoxvirus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Mpox virus positive | 4 | 4 | 4 | 3 | 8 |
| Paramyxoviruses | Ìý | Ìý | Ìý | Ìý | Ìý |
| Measles virus | 15 | 20 | 16 | 10 | 11 |
| Mumps virus | 12 | 9 | 7 | 13 | 13 |
| Plasmodium | Ìý | Ìý | Ìý | Ìý | Ìý |
| Plasmodium falciparum | - | 1 | 1 | 7 | 12 |
| Plasmodium malariae | - | - | - | 1 | - |
| Plasmodium ovale | - | - | - | 1 | 2 |
| Plasmodium vivax | - | - | - | - | 1 |
| Polyomavirus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Polyomavirus BK | 43 | 60 | 60 | 69 | 46 |
| Polyomavirus JC | 9 | 6 | 9 | 7 | 9 |
| Polyomavirus untyped | 17 | 11 | 14 | 20 | 3 |
| Rickettsia | Ìý | Ìý | Ìý | Ìý | Ìý |
| Rickettsia tsutsugamushi | 2 | - | - | - | - |
| Rubella virus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Rubella virus | 2 | 4 | 1 | 1 | 5 |
| Salmonella | Ìý | Ìý | Ìý | Ìý | Ìý |
| Other salmonellas | 46 | 50 | 53 | 49 | 36 |
| Salmonella enteritidis | 17 | 26 | 36 | 31 | - |
| Salmonella java | 7 | - | - | - | - |
| Salmonella kentucky | - | - | - | 5 | - |
| Salmonella newport | - | - | 8 | - | - |
| Salmonella saint-paul | - | 14 | 6 | 8 | - |
| Salmonella sp | 10 | 24 | 42 | 51 | 86 |
| Salmonella typhi and paratyphi | 13 | 15 | 5 | 9 | 13 |
| Salmonella typhimurium | 13 | 28 | 13 | 17 | - |
| Shigella | Ìý | Ìý | Ìý | Ìý | Ìý |
| Shigella boydii | - | 1 | - | 1 | - |
| Shigella dysenteriae | - | - | - | - | 1 |
| Shigella flexneri | 14 | 20 | 15 | 17 | 9 |
| Shigella sonnei | 16 | 13 | 12 | 9 | 18 |
| Shigella sp | 33 | 55 | 62 | 73 | 52 |
| Streptococcus | Ìý | Ìý | Ìý | Ìý | Ìý |
| Streptococcus group A | 73 | 61 | 52 | 60 | 54 |
| Streptococcus pneumoniae | 152 | 181 | 142 | 130 | 146 |
| Vibrio | Ìý | Ìý | Ìý | Ìý | Ìý |
| Vibrio cholerae | 2 | - | 1 | 2 | 1 |
Carbapenemase-producing Enterobacterales (CPE)
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2025/08 | 2025/09 | 2025/10 | 2025/11 | 2025/12 | |
|---|---|---|---|---|---|---|
| Citrobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Citrobacter spp | IMP | - | - | 1 | 1 | - |
| Ìý | KPC | 1 | 3 | - | 1 | 2 |
| Ìý | NDM | 2 | 2 | - | - | - |
| Ìý | OXA48 | - | 4 | 2 | 2 | 2 |
| Ìý | VIM | - | 2 | - | - | - |
| Ìý | Other | 1 | 1 | - | 1 | - |
| Enterobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Enterobacter cloacae complex | IMP | 3 | 4 | 1 | 1 | 1 |
| Ìý | KPC | - | 2 | 2 | - | - |
| Ìý | NDM | 2 | 5 | 10 | 4 | 7 |
| Ìý | OXA48 | 2 | 4 | - | 2 | 1 |
| Ìý | Other | 1 | 2 | - | 1 | - |
| Other enterobacter spp | KPC | - | 1 | - | - | - |
| Ìý | NDM | - | - | - | - | 1 |
| Escherichia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Escherichia coli | KPC | 1 | 3 | 1 | 2 | 1 |
| Ìý | NDM | 15 | 15 | 18 | 15 | 12 |
| Ìý | OXA48 | 20 | 20 | 24 | 17 | 12 |
| Ìý | Other | 2 | 1 | - | 1 | 2 |
| Klebsiella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Klebsiella aerogenes | KPC | - | - | - | - | 1 |
| Ìý | OXA48 | - | 1 | - | - | - |
| Klebsiella oxytoca | IMP | - | - | 1 | - | - |
| Ìý | KPC | - | - | 1 | 1 | - |
| Ìý | NDM | 2 | - | 1 | 1 | - |
| Ìý | OXA48 | 1 | - | 1 | 1 | - |
| Klebsiella pneumoniae | IMP | 1 | - | 2 | - | - |
| Ìý | KPC | 7 | 15 | 6 | 5 | 6 |
| Ìý | NDM | 8 | 8 | 7 | 11 | 8 |
| Ìý | OXA48 | 13 | 9 | 12 | 11 | 5 |
| Ìý | Other | 1 | 3 | - | 2 | 3 |
| Klebsiella variicola | OXA48 | 1 | - | - | - | - |
| Other klebsiella spp | NDM | - | - | - | 1 | - |
| Ìý | Other | - | - | - | 1 | - |
| Morganella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Morganella morganii | NDM | - | 1 | 1 | 1 | - |
| Ìý | OXA48 | - | - | 1 | - | - |
| Pantoea | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Pantoea spp | Other | 1 | - | - | - | - |
| Proteus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Proteus mirabilis | NDM | 2 | 2 | 3 | - | - |
| Ìý | OXA48 | 1 | - | - | - | 1 |
| Ìý | Other | 1 | 1 | 2 | - | - |
| Raoultella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Raoultella ornithinolytica | KPC | - | - | 1 | - | - |
| Ìý | OXA48 | - | 1 | - | - | - |
| Serratia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Serratia marcescens/ureilytica | NDM | - | - | 1 | - | - |
| Ìý | OXA48 | - | 1 | - | - | - |
Other carbapenemase-producing Gram-negative organisms
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to theÌýAMRHAIÌýReference Unit.
| Week notification received | 2025/08 | 2025/09 | 2025/10 | 2025/11 | 2025/12 | |
|---|---|---|---|---|---|---|
| Acinetobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Acinetobacter baumannii | NDM | 2 | 1 | 3 | 1 | - |
| Other acinetobacter spp | NDM | 1 | - | - | - | - |
| Pseudomonas | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Pseudomonas aeruginosa | IMP | 1 | - | - | - | - |
| Ìý | NDM | 2 | 1 | 2 | 1 | - |
| Ìý | Other | 2 | 2 | 1 | 1 | 2 |
| Pseudomonas stutzeri group | NDM | 1 | - | - | - | - |
| Other pseudomonas spp | NDM | - | 1 | 1 | - | - |
| Ìý | VIM | - | 1 | - | - | - |
| Ìý | Other | - | 1 | 1 | - | - |
| Other | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Ìý | KPC | - | 1 | - | - | 1 |
| Ìý | NDM | 1 | - | - | - | - |
| Ìý | OXA48 | 1 | - | - | - | - |