Research and analysis
NOIDs causative agents: week 35 (week ending 3 September 2023)
Updated 2 January 2024
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Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:
- Bacillus anthracis
- Bacillus cereus
- Bordetella pertussis
- Borrelia spp
- Brucella spp
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter spp
- Carbapenemase-producing Gram-negative bacteria
- Chikungunya virus
- Chlamydophila psittaci
- Clostridium botulinum
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- Corynebacterium ulcerans
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Cryptosporidium spp
- Dengue virus
- Ebola virus
- Entamoeba histolytica
- Escherichia coli O 157
- Francisella tularensis
- Giardia lamblia
- Guanarito virus
- Haemophilus influenzae (invasive)
- Hanta virus
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
- Influenza virus
- Junin virus
- Kyasanur Forest disease virus
- Lassa virus
- Legionella spp
- Leptospira interrogans
- Listeria monocytogenes
- Machupo virus
- Marburg virus
- Measles virus
- Mpox (monkeypox) virus
- Mumps virus
- Mycobacterium tuberculosis complex
- Neisseria meningitidis
- Omsk haemorrhagic fever virus
- Plasmodium falciparum
- Plasmodium knowlesi
- Plasmodium malariae
- Plasmodium ovale
- Plasmodium vivax
- Polio virus
- Rabies virus
- Rickettsia spp
- Rift Valley fever virus
- Rubella virus
- Sabia virus
- Salmonella spp
- SARS coronavirus
- Shigella spp
- Streptococcus group A (invasive)
- Streptococcus pneumoniae (invasive)
- Varicella zoster virus
- Variola virus
- Vibrio cholerae
- West Nile virus
- Yellow fever virus
- Yersinia pestis
Statutory notifications of causative agents, grouped by root organism
Totals for the current week compared to the previous 5.
| Week notification received | 2023/30 | 2023/31 | 2023/32 | 2023/33 | 2023/34 | 2023/35 |
|---|---|---|---|---|---|---|
| Arboviruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| West Nile virus | - | - | 2 | - | - | - |
| Bacillus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Bacillus cereus | 15 | 34 | 18 | 28 | 27 | 15 |
| Bordetella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Bordetella pertussis | 10 | 6 | 8 | 14 | 15 | 10 |
| Borrelia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Borrelia burgdorferi | 37 | 67 | 35 | 48 | 52 | 51 |
| Borrelia other named | - | - | - | 1 | - | - |
| Borrelia sp | 4 | 14 | 14 | 16 | 11 | 10 |
| Brucella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Brucella sp | 1 | - | - | - | 1 | - |
| Campylobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Campylobacter coli | 36 | 36 | 45 | 52 | 38 | 28 |
| Campylobacter fetus | - | - | - | 1 | - | - |
| Campylobacter jejuni | 287 | 295 | 339 | 319 | 303 | 216 |
| Campylobacter lari | 1 | 1 | - | - | - | - |
| Campylobacter other named | 2 | 3 | 2 | 1 | 1 | 1 |
| Campylobacter sp | 1,110 | 1,238 | 1,086 | 1,121 | 1,136 | 919 |
| Campylobacter upsaliensis | 2 | - | - | 2 | - | - |
| Campylobacter ureolyticus (bacteroides corrodens) | - | 1 | 1 | 2 | - | - |
| Chikungunya virus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Chikungunya virus | - | 1 | 1 | 1 | 1 | 1 |
| Clostridium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Clostridium perfringens | 28 | 37 | 32 | 22 | 32 | 29 |
| Coronavirus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Coronavirus | 10 | 12 | 11 | 8 | 12 | 6 |
| SARS-CoV-2 antibody indeterminate | 124 | 91 | 75 | 85 | 83 | 76 |
| SARS-CoV-2 antibody void | 6 | 6 | 3 | 5 | 3 | 1 |
| SARS-CoV-2 coronavirus (COVID-19) | 4,298 | 5,550 | 6,715 | 7,134 | 7,263 | 9,189 |
| SARS-CoV-2 coronavirus (COVID-19) indeterminate | 24 | 36 | 76 | 73 | 65 | 171 |
| SARS-CoV-2 IgG antibody negative | 56 | 47 | 49 | 45 | 41 | 31 |
| SARS-CoV-2 IgG antibody positive | 154 | 149 | 144 | 164 | 198 | 151 |
| SARS-CoV-2 total antibody negative | 38 | 64 | 62 | 62 | 65 | 64 |
| SARS-CoV-2 total antibody positive | 94 | 151 | 139 | 148 | 162 | 165 |
| Corynebacterium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Corynebacterium diphtheriae | 4 | 3 | 1 | 6 | 2 | 3 |
| Corynebacterium ulcerans | - | - | 1 | - | - | - |
| Coxiella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Coxiella burnetii | - | 1 | 1 | - | - | - |
| Cryptosporidium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Cryptosporidium cuniculus | - | - | 1 | 1 | - | - |
| Cryptosporidium felis | - | 3 | - | - | - | - |
| Cryptosporidium hominis | 17 | 11 | 27 | 42 | 57 | 10 |
| Cryptosporidium meleagridis | 1 | - | - | 1 | - | - |
| Cryptosporidium parvum | 32 | 38 | 49 | 59 | 62 | 23 |
| Cryptosporidium sp | 26 | 32 | 27 | 45 | 75 | 170 |
| Cryptosporidium ubiquitum | 2 | - | - | 1 | 1 | - |
| Entamoeba | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Entamoeba histolytica | 1 | 2 | 2 | 2 | 2 | - |
| Escherichia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Escherichia coli O 157 | 18 | 16 | 16 | 5 | 15 | 14 |
| Flaviviruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Dengue virus | 3 | 9 | 7 | 3 | 6 | 5 |
| Haemophilus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Haemophilus influenzae | 58 | 46 | 68 | 58 | 48 | 35 |
| Hepatitis viruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Hepatitis A | 11 | 10 | 9 | 6 | 11 | 6 |
| Hepatitis B | 271 | 258 | 305 | 276 | 260 | 212 |
| Hepatitis C | 339 | 448 | 348 | 367 | 348 | 290 |
| Hepatitis D | 5 | 1 | 2 | 9 | 5 | 3 |
| Hepatitis E | 32 | 36 | 33 | 20 | 26 | 28 |
| Influenza virus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Influenza A | 57 | 65 | 53 | 49 | 44 | 51 |
| Influenza B | 17 | 12 | 22 | 10 | 23 | 9 |
| Influenza ungrouped | - | 6 | 5 | 2 | 2 | - |
| Legionella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Legionella longbeachae | - | - | 1 | 1 | - | - |
| Legionella other named | - | 1 | - | - | - | - |
| Legionella pneumophila | 17 | 13 | 6 | 5 | 12 | 7 |
| Legionella sp | 8 | 7 | 7 | 9 | 3 | 6 |
| Listeria | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Listeria monocytogenes | 2 | 9 | 2 | 3 | 4 | 2 |
| Mycobacterium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Mycobacterium tuberculosis | 83 | 77 | 115 | 98 | 66 | 52 |
| Neisseria | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Neisseria meningitidis | 22 | 17 | 14 | 15 | 184 | 12 |
| Orthopoxvirus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Mpox virus | 3 | 4 | 3 | 1 | 2 | 3 |
| Paramyxoviruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Measles virus | 4 | 2 | - | 1 | 1 | 1 |
| Mumps virus | 4 | 3 | 7 | 2 | - | 5 |
| Plasmodium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Plasmodium falciparum | 1 | 11 | 21 | - | 1 | 4 |
| Plasmodium ovale | - | - | 2 | - | - | - |
| Plasmodium vivax | - | - | 3 | - | - | - |
| Polyomavirus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Polyomavirus BK | 39 | 50 | 45 | 64 | 50 | 22 |
| Polyomavirus JC | 9 | 5 | 7 | 15 | 11 | 6 |
| Polyomavirus untyped | 1 | - | - | - | - | 2 |
| Rickettsia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Rickettsia prowazekii | - | 2 | - | - | - | 1 |
| Rickettsia sp | - | - | - | 1 | - | - |
| Rickettsia spotted fever | - | 1 | - | - | - | - |
| Rubella virus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Rubella virus | 3 | 2 | 1 | - | 3 | 2 |
| Salmonella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Other salmonellas | 64 | 73 | 65 | 62 | 33 | 16 |
| Salmonella agona | - | 5 | - | - | - | - |
| Salmonella chester | - | - | 10 | - | - | - |
| Salmonella enteritidis | 40 | 60 | 106 | 62 | 39 | 21 |
| Salmonella haifa | - | - | 5 | - | - | - |
| Salmonella infantis | 8 | 12 | 9 | 20 | 8 | - |
| Salmonella java | - | 8 | 5 | - | - | - |
| Salmonella newport | - | - | - | 9 | - | - |
| Salmonella sp | 27 | 26 | 28 | 58 | 177 | 169 |
| Salmonella typhi and paratyphi | 6 | 6 | 11 | 16 | 7 | 10 |
| Salmonella typhimurium | 33 | 39 | 43 | 39 | 23 | 10 |
| Salmonella virchow | - | 6 | - | - | - | - |
| Salmonella enterica | - | - | 5 | - | - | - |
| Shigella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Shigella boydii | - | - | - | - | 4 | 1 |
| Shigella dysenteriae | 1 | 1 | - | 1 | - | - |
| Shigella flexneri | 10 | 11 | 11 | 10 | 8 | 8 |
| Shigella sonnei | 26 | 31 | 17 | 27 | 27 | 12 |
| Shigella sp | 49 | 56 | 53 | 56 | 81 | 75 |
| Streptococcus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Streptococcus group A | 56 | 68 | 70 | 51 | 65 | 60 |
| Streptococcus pneumoniae | 63 | 81 | 72 | 66 | 63 | 50 |
| Vibrio | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Vibrio cholerae | 3 | 1 | 2 | 4 | 2 | 4 |
Carbapenemase-producing Enterobacterales (CPE)
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/30 | 2023/31 | 2023/32 | 2023/33 | 2023/34 | 2023/35 | |
|---|---|---|---|---|---|---|---|
| Citrobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Citrobacter spp | IMP | - | - | - | 1 | 1 | - |
| Ìý | KPC | 1 | 2 | 3 | 1 | - | 1 |
| Ìý | NDM | - | 1 | - | 2 | 2 | - |
| Ìý | OXA48 | 5 | 2 | 4 | 2 | 3 | - |
| Ìý | VIM | - | 1 | - | 1 | - | - |
| Ìý | Other | - | - | - | 1 | 1 | - |
| Cronobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Cronobacter spp | KPC | - | - | - | 1 | - | - |
| Enterobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Enterobacter cloacae complex | IMP | 2 | - | 2 | 1 | 1 | - |
| Ìý | KPC | 9 | 3 | 7 | 5 | 8 | 5 |
| Ìý | NDM | 3 | 4 | 5 | 6 | 7 | 2 |
| Ìý | OXA48 | 2 | 3 | - | 2 | 1 | 1 |
| Ìý | VIM | 1 | - | - | - | 2 | - |
| Ìý | Other | 1 | 1 | - | 2 | 1 | - |
| Other enterobacter spp | IMP | - | 1 | - | 1 | 1 | - |
| Ìý | NDM | 2 | - | 1 | - | - | - |
| Ìý | OXA48 | - | - | - | 1 | 1 | - |
| Ìý | VIM | 1 | - | - | - | 3 | - |
| Escherichia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Escherichia coli | IMP | 1 | - | 1 | - | - | 1 |
| Ìý | KPC | 7 | 6 | 6 | 4 | 2 | 4 |
| Ìý | NDM | 11 | 9 | 9 | 14 | 12 | 2 |
| Ìý | OXA48 | 6 | 13 | 10 | 23 | 19 | 5 |
| Ìý | Other | - | 1 | - | 1 | 1 | 1 |
| Escherichia hermannii | KPC | 1 | - | - | - | - | - |
| Klebsiella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Klebsiella aerogenes | KPC | 1 | - | - | - | 1 | - |
| Ìý | NDM | - | - | - | - | 1 | - |
| Klebsiella | OXA48 | - | - | 2 | - | - | - |
| Ìý | Other | - | - | - | 1 | - | - |
| Klebsiella oxytoca | IMP | - | - | - | - | 1 | - |
| Ìý | KPC | 3 | 2 | 5 | - | - | - |
| Ìý | NDM | 1 | 2 | - | - | - | - |
| Ìý | OXA48 | 1 | 1 | 4 | 1 | - | 1 |
| Klebsiella pneumoniae | IMP | - | - | - | 1 | 2 | 1 |
| Ìý | KPC | 6 | 6 | 8 | 15 | 9 | 7 |
| Ìý | NDM | 6 | 3 | 7 | 10 | 2 | - |
| Ìý | OXA48 | 9 | 7 | 7 | 5 | 9 | - |
| Ìý | VIM | - | - | - | 1 | - | - |
| Ìý | Other | 1 | - | - | 1 | - | - |
| Klebsiella variicola | OXA48 | - | - | 1 | - | 1 | - |
| Other klebsiella spp | OXA48 | - | - | 1 | - | - | - |
| Morganella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Morganella morganii | KPC | - | - | - | 1 | - | - |
| Ìý | NDM | - | - | - | 1 | - | - |
| Ìý | OXA48 | 1 | - | - | 1 | - | - |
| Ìý | VIM | - | - | - | 1 | - | - |
| Proteus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Proteus mirabilis | IMP | - | - | - | - | - | 1 |
| Ìý | NDM | 2 | - | - | - | - | - |
| Ìý | OXA48 | 1 | 1 | - | - | 1 | - |
| Providencia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Providencia spp | NDM | - | 1 | - | - | - | - |
| Raoultella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Raoultella ornithinolytica | KPC | - | 1 | - | - | - | - |
| Serratia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Serratia marcescens/ureilytica | OXA48 | 1 | - | 1 | - | - | - |
| Ìý | Other | - | - | 1 | - | - | - |
| Other serratia spp | NDM | 1 | - | - | - | - | - |
| Ìý | OXA48 | 1 | - | - | - | - | - |
Other carbapenemase-producing Gram-negative organisms
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/30 | 2023/31 | 2023/32 | 2023/33 | 2023/34 | 2023/35 | |
|---|---|---|---|---|---|---|---|
| Acinetobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Acinetobacter baumannii | IMP | - | 1 | - | - | - | - |
| Ìý | NDM | 1 | - | - | - | - | - |
| Other acinetobacter spp | Other | - | - | 1 | - | - | - |
| Pseudomonas | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Pseudomonas aeruginosa | IMP | - | - | 1 | - | 1 | - |
| Ìý | NDM | 4 | 1 | - | 2 | - | - |
| Ìý | VIM | 1 | - | - | - | - | - |
| Ìý | Other | 1 | 2 | 1 | 1 | 1 | 1 |
| Pseudomonas fluorescens group | VIM | - | - | - | 1 | - | - |
| Pseudomonas nitroreducens | VIM | 1 | - | - | - | - | - |
| Pseudomonas putida group | VIM | 1 | - | - | - | - | - |
| Ìý | Other | 1 | - | - | - | - | - |
| Other pseudomonas spp | VIM | - | 1 | 1 | - | - | - |
| Other | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Ìý | OXA48 | - | - | 2 | - | - | - |