Routine implementation of isoniazid preventive therapy in HIV-infected patients in seven pilot sites in Zimbabwe
IPT completion rates were comparatively high, showing that IPT roll-out in public health facilities is feasible
Abstract
Setting
7 pilot sites in Zimbabwe implementing 6 months of isoniazid preventive therapy (IPT) for people living with the human immunodeficiency virus (PLHIV).
Objectives
To determine, among PLHIV started on IPT, the completion rates for a 6-month course of IPT and factors associated with non-adherence.
Design
A retrospective cohort study.
Results
Of 578 patients, 466 (81%) completed IPT. Of the 112 patients who failed to complete IPT, 69 (60%) were lost to follow-up, 30 (27%) stopped treatment with no documented reasons, 8 (7%) developed toxicity/adverse reactions, 5 (5%) were documented as having drug stock-outs and the remainder transferred out or refused to continue treatment. Currently being on antiretroviral therapy (ART) (aOR 0.09, 95%CI 0.03바카라 사이트“0.28) and receiving a 2 month supply of isoniazid at the start of treatment were associated with a lower risk of not completing IPT, while missing clinic visits prior to starting IPT (aOR 5.25, 95%CI 2.10바카라 사이트“13.14) was associated with a higher risk of non-completion.
Conclusion
IPT completion rates in seven pilot sites of Zimbabwe were comparatively high, showing that IPT roll-out in public health facilities is feasible. Enhanced adherence counselling or active tracing among pre-ART patients and those with a history of loss to follow-up may improve IPT completion rates, along with synchronising IPT and ART resupplies.
This research was supported by the UK Department for International Development바카라 사이트™s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Citation
Takarinda KC, Choto RC, Harries AD, Mutasa-Apollo T, Chakanyuka-Musanhu C. Routine implementation of isoniazid preventive therapy in HIV-infected patients in seven pilot sites in Zimbabwe. Public Health Action. 2017;7(1):55바카라 사이트“60.