Effect of Universal Testing and Treatment on HIV Incidence - HPTN 071 (PopART).
This study involved communities in Zambia and South Africa
Abstract
A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV) infection, yet previous trial results are inconsistent.
In the HPTN 071 (PopART) community-randomized trial conducted from 2013 through 2018, the authors randomly assigned 21 communities in Zambia and South Africa (total population, approximately 1 million) to group A (combination prevention intervention with universal antiretroviral therapy [ART]), group B (the prevention intervention with ART provided according to local guidelines [universal since 2016]), or group C (standard care). The prevention intervention included home-based HIV testing delivered by community workers, who also supported linkage to HIV care and ART adherence. The primary outcome, HIV incidence between months 12 and 36, was measured in a population cohort of approximately 2000 randomly sampled adults (18 to 44 years of age) per community. Viral suppression (< 400 copies of HIV RNA per milliliter) was assessed in all HIV-positive participants at 24 months.
This research was supported by the UK Department for International Development바카라 사이트™s Operational Research Capacity Building Programme led by the International Union Against TB and Lung Disease (The Union)
Citation
Harries AD, Takarinda KC. F1000Prime Recommendation of [Hayes RJ et al., N Engl J Med 2019 381(3):207-218]. F1000 Prime. 2019. Available from: https://f1000.com/prime/736207432#eval793564775