Down바카라 사이트s syndrome, Edwards바카라 사이트 syndrome and Patau바카라 사이트s syndrome screening pathway
Updated 30 January 2025
Applies to England
Β© Crown copyright 2025
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This flowchart (text description and illustration below) describes the screening pathway for Down바카라 사이트s syndrome, Edwards바카라 사이트 syndrome and Patau바카라 사이트s syndrome including non-invasive prenatal testing (NIPT).
1. Offer information and screening for T21, T18 and T13
Offer the pregnant woman screening for Down바카라 사이트s syndrome (trisomy 21), Edwards바카라 사이트 syndrome (trisomy 18) and Patau바카라 사이트s syndrome (trisomy 13) and information about the screening test(s).
Before screening is carried out, the baby바카라 사이트s crown rump length (CRL) is measured at the .
2. Does the woman accept screening?
Yes: The woman accepts screening for:
- Down바카라 사이트s syndrome, Edwards바카라 사이트 syndrome and Patau바카라 사이트s syndrome
- Edwards바카라 사이트 syndrome and Patau바카라 사이트s syndrome
- Downs바카라 사이트 syndrome only
Go to question 3.
No: Offer 20-week screening scan. End of pathway.
3. Is the baby바카라 사이트s CRL less than 45.0mm?
Yes: Recall the woman for a repeat scan when CRL measures 45.0mm or more. Then go to question 4.
No: Go to question 4.
4. Is the baby바카라 사이트s CRL between 45.0mm and 84.0mm?
Yes: Carry out combined screening test for chosen conditions. Go to question 7.
No: Go to question 5.
Please note: if it is not possible to measure the baby바카라 사이트s nuchal translucency (NT) despite 2 attempts (바카라 사이트twice on the couch바카라 사이트), further attempts do not need to be offered. The woman should be offered quadruple screening.
5. Is the baby바카라 사이트s head circumference (HC) between 101.0mm and 172.0mm
Yes: Offer T21 quadruple screening (Down바카라 사이트s syndrome only). Go to question 6.
No: Offer 20-week screening scan. End of pathway.
6. Does the woman accept quadruple screening?
Yes: Carry out quadruple test. Go to question 7.
No: Offer 20-week screening scan. End of pathway.
7. Is the result lower chance?
Yes: Offer 20-week screening scan. End of pathway.
No: Refer for discussion of further choices. Go to question 8.
8. Does the woman want further tests?
Yes: Go to question 9.
No: Offer 20-week screening scan. End of pathway.
9. Which test does the woman want?
NIPT: Carry out NIPT. Go to question 10.
CVS or amniocentesis: Carry out CVS or amniocentesis test. Go to question 12.
10. What is the result of NIPT?
Lower chance result: Offer 20-week screening scan. End of pathway.
Higher chance result: Discuss options. Go to question 11.
11. Does the woman want further tests?
Yes: Carry out CVS or amniocentesis test. Go to question 12.
No: Offer 20-week screening scan and follow-up support. End of pathway.
12. Does baby have Down바카라 사이트s syndrome, Edwards바카라 사이트 syndrome or Patau바카라 사이트s syndrome?
Yes: Discuss options with the woman. Go to question 13.
No: Offer 20-week screening scan. End of pathway.
13. What is the woman바카라 사이트s choice?
Continue pregnancy: Offer 20-week screening scan and follow-up support. End of pathway.
Terminate pregnancy: Offer follow-up support.