Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg): do not use in patients with cows바카라 사이트™ milk allergy
Solu-Medrone 40 mg may contain trace amounts of milk proteins. Do not use in patients with a known or suspected allergy to cows바카라 사이트™ milk.
Post-publication note
In November 2020, Solu-Medrone 40 mg was reformulated to a lactose-free formulation in which the lactose was replaced by sucrose 바카라 사이트” see .
Advice for healthcare professionals:
- Solu-Medrone 40 mg uses lactose produced from cows바카라 사이트™ milk as an excipient and may contain trace amounts of milk proteins; other strengths of Solu-Medrone do not contain lactose
- serious allergic reactions have been reported in patients allergic to cows바카라 사이트™ milk proteins
- do not use injectable methylprednisolone medicines that contain lactose in patients with a known or suspected allergy to cows바카라 사이트™ milk
- if a patient바카라 사이트™s symptoms worsen or any new allergic symptoms occur, allergic reaction to cows바카라 사이트™ milk proteins should be suspected; stop administration of the product and treat the patient바카라 사이트™s condition accordingly
European review
Methylprednisolone is a corticosteroid with a wide variety of indications including allergic states, dermatological disease, and gastrointestinal diseases.
A recent EU review reported cases of allergic reactions, including bronchospasm and anaphylaxis, in patients allergic to cows바카라 사이트™ milk proteins treated with injectable methylprednisolone products containing lactose of bovine origin. Most patients were younger than 12 years and had childhood asthma. In some of the reported cases the adverse reaction was misinterpreted as a lack of therapeutic effect, leading to re-administration of methylprednisolone and subsequent worsening of the clinical condition of the patient.
Lactose-containing methylprednisolone medicines will be reformulated to remove any trace of milk proteins. Companies have been asked to take steps towards lactose-free formulations by 2019.
In the meantime, a has been sent to communicate the new restriction and warnings.
About cows바카라 사이트™ milk allergy
Cows바카라 사이트™ milk allergy is an adverse reaction of an immunological nature induced by cows바카라 사이트™ milk proteins. Estimates of prevalence of cows바카라 사이트™ milk allergy based on food challenge vary from 0% to 3%. Most children outgrow their allergy in early childhood and only a small proportion of patients remain allergic in adulthood.
Cows바카라 사이트™ milk allergy should be clearly distinguished from lactose intolerance, which is a non-immunologically mediated reaction to milk caused by a lack of the enzyme lactase in the small intestine, which breaks lactose from milk down into glucose and galactose.
Call for reporting
Any suspected adverse reactions, including during treatment of allergic conditions, should be reported to us on a .
Further information
. Solu-Medrone 40 mg. October 2017.
. August 2017.
Article citation: Drug Safety Update volume 11 issue 3, October 2017: 1.