Research and analysis
Annex 2: Table 3
Updated 28 June 2021
| 锘縎tudy | Includes erythromycin, azithromycin or clarithromycin | Includes outcome of interest (MCM, CVM or miscarriage) | Comparator | Included or excluded | Reason for exclusion |
|---|---|---|---|---|---|
| Muanda FT, Sheehy O, Berard A. Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study. Br J Clin Pharmacol. 2017;83(11):2557바카라 사이트�71. https://doi.org/10.1111/bcp.13364 | yes (erythromycin, azithromycin and clarithromycin) | MCM, CVM | unexposed | included | N/A |
| Romoren M, Lindbaek M, Nordeng H. Pregnancy outcome after gestational exposure to erythromycin바카라 사이트攁 population바카라 사이트恇ased register study from Norway. Br J Clin Pharmacol. 2012;74(6):1053바카라 사이트�62. https ://doi.org/10.1111/j.1365바카라 사이트�2125.2012.04286 .x. | yes (erythromycin, azithromycin and clarithromycin) | MCM, CVM | unexposed | included | N/A |
| Cooper WO, Hernandez바카라 사이트怐iaz S, Arbogast PG, Dudley JA, Dyer SM, Gideon PS, et al. Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations. Paediatr Perinat Epidemiol. 2008;23(1):18바카라 사이트�28. https ://doi.org/10.1111/j.1365바카라 사이트�3016.2008.00978 .x | yes (azithromycin, erythromycin) | MCM | unexposed | included | N/A |
| Lund M, Pasternak B, Davidsen RB, Feenstra B, Krogh C, Diaz LJ, et al. Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study. BMJ. 2014;348:g1908. https://doi.org/10.1136/bmj.g1908 | any macrolide | no (pyloric stenosis) | N/A (case-control) | excluded | did not study outcome of interest |
| L锚 Nguy锚n T, Araujo M, Hurault바카라 사이트怐elarue C, Lacroix I, Damase바카라 사이트怣ichel C, Sommet A. Teratogenic risk of macrolides during the first trimester of pregnancy: a study with two complementary approaches within the EFEMERIS database. Clin Ther. 2017;39(8):e11바카라 사이트�2. | any macrolide | congenital malformations | unexposed women and women exposed to penicillin | excluded | no individual analysis per macrolide (also could only find an abstract so limited detail) |
| Einarson A, Phillips E, Mawji F, D바카라 사이트橝limonte D, Schick B, Addis A, et al. A prospective controlled multicentre study of clarithromycin in pregnancy. Am J Perinatol. 1998;15(9):523바카라 사이트�5. https ://doi.org/10.1055/s바카라 사이트�2007바카라 사이트�99405 3. | yes (clarithromycin) | MCM, miscarriage (spontaneous abortion) | women exposed to a nonteratogen with a similar indication to clarithromycin | excluded | mixed comparator group, only event rates presented |